Impact of Bioreactor Geometry on Mesenchymal Stem Cell Production in Stirred?Tank Bioreactors
نویسندگان
چکیده
Human mesenchymal stem cells (hMSCs) are manufactured as cell therapy products. This requires a tightly controlled and fully understood production process, usually taking place in stirred-tank bioreactor. In this review, the impact of bioreactor geometry well equipment-related parameters is discussed. We provide theoretical background for engineering hMSC spheroids with defined size evaluate process needed microcarrier-based expansion hMSCs. Finally, based on experimental data, ideal setups each type recommended.
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ژورنال
عنوان ژورنال: Chemie Ingenieur Technik
سال: 2021
ISSN: ['0009-286X', '1522-2640']
DOI: https://doi.org/10.1002/cite.202100041